The purpose of this article is to consturct the problematics of the semiotics of Covid-19. There are three main dimensions of this inquiry which are agentivity, narrativity, temporality. In the first section, the author attempted to apprehend 6 semiotic features of the pandemic which are ethical, political, axiological, ontological, epistemological, methodological. In the second section, some semiotic isotopies of the narrative discursivity of the Covid-19 are suggested. In terms of the temporality, the non-linearity is underlined. In conclusion, this work insisted on the necessity of constructing the concept of deep narrativity and the infinite responsibility of the human beings.